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Article

The opioid system in alcohol and drug dependence: family-based association study.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Oct 2007

Xuei Xiaoling, Flury-Wetherill Leah, Bierut Laura, Dick Danielle, Nurnberger John, Foroud Tatiana, Edenberg Howard J

Abstract excerpt

Opioid receptors and their endogenous peptide ligands play important roles in neurotransmission and neuromodulation in response to addictive drugs such as heroin, cocaine, and alcohol. In an earlier study, we reported that variation in the genes encoding the kappa-opioid receptor (OPRK1) and its peptide ligand (PDYN) were associated with the risk for alcoholism. We continued our investigation of the role of the...

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Source

Identifiers

PMID: 17503481
DOI: 10.1002/ajmg.b.30531

Genes

PENK
POMC
OPRD1
OPRM1
OPRK1
PDYN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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