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Article

Evidence for association of two variants of the nociceptin/orphanin FQ receptor gene OPRL1 with vulnerability to develop opiate addiction in Caucasians.

Psychiatric genetics - 1 Apr 2010

Briant Judith A, Nielsen David A, Proudnikov Dmitri, Londono Douglas, Ho Ann, Ott Jurg, Kreek Mary Jeanne

Abstract excerpt

OBJECTIVES: The OPRL1 gene encodes the nociceptin/orphanin FQ receptor, which plays a role in regulating tolerance and behavioral responses to morphine. However, there is limited information on whether variants of OPRL1 are associated with vulnerability to develop opiate addiction. In this study,...

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Identifiers

PMID: 20032820
DOI: 10.1097/YPG.0b013e32833511f6
PMCID: PMC3832186

Genes

OPRL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20032820-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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