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Article

The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1.

Nature cell biology - 1 Nov 2007

Plun-Favreau Hélène, Klupsch Kristina, Moisoi Nicoleta, Gandhi Sonia, Kjaer Svend, Frith David, Harvey Kirsten, Deas Emma, Harvey Robert J, McDonald Neil, Wood Nicholas W, Martins L Miguel, Downward Julian

Abstract excerpt

In mice, targeted deletion of the serine protease HtrA2 (also known as Omi) causes mitochondrial dysfunction leading to a neurodegenerative disorder with parkinsonian features. In humans, point mutations in HtrA2 are a susceptibility factor for Parkinson's disease (PARK13 locus). Mutations in PINK1, a putative mitochondrial protein kinase, are associated with the PARK6 autosomal recessive locus for susceptibility...

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Source

Identifiers

PMID: 17906618
DOI: 10.1038/ncb1644

Genes

PINK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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