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What have PINK1 and HtrA2 genes told us about the role of mitochondria in Parkinson's disease?

Annals of the New York Academy of Sciences - 1 Dec 2008

Plun-Favreau Helene, Gandhi Sonia, Wood-Kaczmar Alison, Deas Emma, Yao Zhi, Wood Nicholas W

Abstract excerpt

Parkinson's disease (PD) is a common, disabling, neurodegenerative disease. Our knowledge of the molecular events leading to PD is being greatly enhanced by the study of relatively rare familial form of the disease. Nevertheless, the pathways leading from the genetic mutations to nigral cell degeneration and the other features in PD remain poorly understood. The identification of PINK1, a mitochondrial putative...

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Source

Identifiers

PMID: 19076428
DOI: 10.1196/annals.1427.032

Genes

PINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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