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Article

Loss of GSK-3β mediated phosphorylation in HtrA2 contributes to uncontrolled cell death with Parkinsonian phenotype.

International journal of biological macromolecules - 1 Jun 2021

Bose Kakoli, Wagh Ajay, Mishra Vasudha, Dutta Shubhankar, Parui Aasna L, Puja Rashmi, Mudrale Snehal Pandav, Kulkarni Suyamindra S, Gai Pramod B, Sarin Rajiv

Abstract excerpt

HtrA2, a proapoptotic mitochondrial serine protease, promotes cellular protection against oxidative damage. Literature reports show positive correlation between loss of HtrA2 protease activity and Parkinson's Disease (PD) susceptibility. Homozygous loss-of-function mutations in murine-HtrA2, and when they rarely occur in humans result in severe neurodegeneration and infantile death. Here, we report a novel...

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PMID: 33716130
DOI: 10.1016/j.ijbiomac.2021.03.040

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