Article
Beta-amyloid precursor protein is a direct cleavage target of HtrA2 serine protease. Implications for the physiological function of HtrA2 in the mitochondria.
The Journal of biological chemistry - 10 Nov 2006
Park Hyo-Jin, Kim Sang-Soo, Seong Young-Mo, Kim Kyung-Hee, Goo Hui Gwan, Yoon Eun Jin, Min Do Sik, Kang Seongman, Rhim Hyangshuk
Abstract excerpt
The processing and metabolism of amyloid precursor protein (APP) is a major interest in Alzheimer disease (AD) research, because not only amyloid beta (Abeta) peptide, but also cellular or mitochondrial APP are intimately involved in cellular dysfunction and AD pathogenesis. Here we demonstrate that APP is directly and efficiently cleaved by the HtrA2 serine protease in vitro and in vivo. Using several APP...
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