Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes

25 May 2018

Abstract excerpt

Activation of the inflammasome pathway is crucial for effective intracellular host defense. The mitochondrial network plays an important role in inflammasome regulation but the mechanisms linking mitochondrial homeostasis to attenuation of inflammasome activation are not fully understood. Here, we report that the Parkinson's disease-associated mitochondrial serine protease HtrA2 restricts the activation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Heme Oxygenase-1 and Carbon Monoxide
Share to Inflammasome and immune disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29855523
DOI: 10.1038/s41598-018-26603-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomesPMID 29855523Read ↗

Mitochondrial Quality Control and Restraining Innate ImmunitySemantic proximity Read ↗

Inflammasome and Mitophagy Connection in Health and DiseaseSemantic proximity Read ↗

The mitochondrial serine protease HtrA2/Omi: an overviewSemantic proximity Read ↗

The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1.Semantic proximity Read ↗

Progress in research on the role of Omi/HtrA2 in neurological diseasesSemantic proximity Read ↗

Mitochondrial defects and neurodegeneration in mice overexpressing wild-type or G399S mutant HtrA2.Semantic proximity Read ↗

Bat ASC2 suppresses inflammasomes and ameliorates inflammatory diseasesSemantic proximity Read ↗

ATP13A2 restrains macrophage NLRP3 inflammasome activation to repress neurodegeneration via modulating mitochondrial homeostasis.Semantic proximity Read ↗

Pharmacologic Targeting of PDIA1 Inhibits NLRP3 Inflammasome Assembly and ActivationSemantic proximity Read ↗

Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagySemantic proximity Read ↗

SARS-CoV-2 papain-like protease inhibits IL-1β maturation and pyroptosis through disruption of ASC oligomerization and deubiquitination of ASCSemantic proximity Read ↗

Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.