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Article

Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin.

Cell death and differentiation - 1 Aug 2009

Tain L S, Chowdhury R B, Tao R N, Plun-Favreau H, Moisoi N, Martins L M, Downward J, Whitworth A J, Tapon N

Abstract excerpt

High temperature requirement A2 (HtrA2/Omi) is a mitochondrial protease that exhibits proapoptotic and cell-protective properties and has been linked to Parkinson's disease (PD). Impaired mitochondrial function is a common trait in PD patients, and is likely to play a significant role in pathogenesis of parkinsonism, but the molecular mechanisms remain poorly understood. Genetic studies in Drosophila have...

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Identifiers

PMID: 19282869
DOI: 10.1038/cdd.2009.23
PMCID: PMC2711053

Genes

PINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin.PMID 19282869Read ↗

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