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Genome-Wide Expression and Location Analyses of the Candida albicans Tac1p Regulon

29 Sept 2007

Abstract excerpt

A major mechanism of azole resistance in Candida albicans is overexpression of the genes encoding the ATP binding cassette transporters Cdr1p and Cdr2p due to gain-of-function mutations in Tac1p, a transcription factor of the zinc cluster family. To identify the Tac1p regulon, we analyzed four matched sets of clinical isolates representing the development of CDR1- and CDR2-mediated azole resistance by using gene...

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PMID: 17905926
DOI: 10.1128/ec.00327-07

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Genome-Wide Expression and Location Analyses of the Candida albicans Tac1p RegulonPMID 17905926Read ↗

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