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Article

Relative Contributions of the <i>Candida albicans</i> ABC Transporters Cdr1p and Cdr2p to Clinical Azole Resistance

18 Feb 2009

Abstract excerpt

Candida albicans frequently develops resistance to treatment with azole drugs due to the acquisition of gain-of-function mutations in the transcription factor Tac1p. Tac1p hyperactivation in azole-resistant isolates results in the constitutive overexpression of several genes, including CDR1 and CDR2, which encode two homologous transporters of the ATP-binding cassette family. Functional studies of Cdr1p and Cdr2p...

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PMID: 19223631
DOI: 10.1128/aac.00926-08

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Relative Contributions of the <i>Candida albicans</i> ABC Transporters Cdr1p and Cdr2p to Clinical Azole ResistancePMID 19223631Read ↗

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