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Article

The H741D mutation in Tac1p contributes to the upregulation of CDR1 and CDR2 expression in Candida albicans.

Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] - 1 Dec 2020

Liu Jin-Yan, Wei Bing, Wang Ying, Shi Ce, Li Wen-Jing, Zhao Yue, Meng Ling-Ning, Xiang Ming-Jie

Abstract excerpt

The wide use of antifungal agents has led to the development of resistance in the pathogenic yeast strain Candida albicans. Gain-of-function mutations in transcription factors such as Tac1p demonstrated their ability to control expression of the ABC transporter genes CDR1 and CDR2, and mediation of azole resistance. Previously, we obtained a series of azole-resistant isolates with high-level expression of CDR1...

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Identifiers

PMID: 32648240
DOI: 10.1007/s42770-020-00336-8
PMCID: PMC7688751

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The H741D mutation in Tac1p contributes to the upregulation of CDR1 and CDR2 expression in Candida albicans.PMID 32648240Read ↗

The TAC1 Gene in Candida albicans: Structure, Function, and Role in Azole Resistance: A Mini-Review.Semantic proximity Read ↗

A mutation in Tac1p, a transcription factor regulating CDR1 and CDR2, is coupled with loss of heterozygosity at chromosome 5 to mediate antifungal resistance in Candida albicans.Semantic proximity Read ↗

Relative Contributions of the <i>Candida albicans</i> ABC Transporters Cdr1p and Cdr2p to Clinical Azole ResistanceSemantic proximity Read ↗

TAC1, transcriptional activator of CDR genes, is a new transcription factor involved in the regulation of Candida albicans ABC transporters CDR1 and CDR2.Semantic proximity Read ↗

Genome-Wide Expression and Location Analyses of the Candida albicans Tac1p RegulonSemantic proximity Read ↗

Mutations in <i>TAC1B</i> drive <i>CDR1</i> and <i>MDR1</i> expression and azole resistance in <i>C. auris</i>Semantic proximity Read ↗

Mediator Tail Module Is Required for Tac1-Activated CDR1 Expression and Azole Resistance in Candida albicans.Semantic proximity Read ↗

Mutations in TAC1B drive increased CDR1 and MDR1 expression and azole resistance in Candida auris.Semantic proximity Read ↗

Atomic modelling and systematic mutagenesis identify residues in multiple drug binding sites that are essential for drug resistance in the major Candida transporter Cdr1.Semantic proximity Read ↗

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Evolutionary diversity of the control of the azole response by Tra1 across yeast speciesSemantic proximity Read ↗

Update on the structure and function of Candida albicans drug efflux protein, Cdr1Semantic proximity Read ↗

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