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Article

Recurrent mutations in the stress regulator Cap1 reveal a trade-off between azole resistance and oxidative stress response in Candida albicans.

PLoS biology - 1 Feb 2026

Zhou Xin, Hilk Audrey, Solis Norma V, Scott Nancy, Zajac Christopher, Filler Scott G, Selmecki Anna

Abstract excerpt

Drug resistance is a critical challenge in treating life-threatening fungal infections. Here, we uncover a mechanism of acquired azole resistance in Candida albicans through mutations in CAP1, encoding a conserved fungal transcription factor that mediates the oxidative stress response. We analyzed 300 clinical isolates and identified 25 distinct CAP1 missense or nonsense mutations, with many occurring within the...

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Identifiers

PMID: 41628278
DOI: 10.1371/journal.pbio.3003631
PMCID: PMC12904577

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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