Article
Human heart failure is associated with abnormal C-terminal splicing variants in the cardiac sodium channel.
Circulation research - 26 Nov 2007
Shang Lijuan L, Pfahnl Arnold E, Sanyal Shamarendra, Jiao Zhe, Allen Jon, Banach Kathrin, Fahrenbach John, Weiss Daiana, Taylor W Robert, Zafari A Maziar, Dudley Samuel C
Abstract excerpt
Heart failure (HF) is associated with reduced cardiac Na+ channel (SCN5A) current. We hypothesized that abnormal transcriptional regulation of this ion channel during HF could help explain the reduced current. Using human hearts explanted at the transplantation, we have identified 3 human C-terminal SCN5A mRNA splicing variants predicted to result in truncated, nonfunctional channels. As compared with normal...
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