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Article

Unfolded Protein Response Regulates Cardiac Sodium Current in Systolic Human Heart Failure

14 Sept 2013

Abstract excerpt

BACKGROUND: Human heart failure (HF) increases alternative mRNA splicing of the type V, voltage-gated cardiac Na+ channel α-subunit (SCN5A), generating variants encoding truncated, nonfunctional channels that are trapped in the endoplasmic reticulum. In this work, we tested whether truncated Na+ channels activate the unfolded protein response (UPR), contributing to SCN5A electric remodeling in HF. METHODS AND...

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PMID: 24036084
DOI: 10.1161/circep.113.000274

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