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Article

Cloning and initial characterization of the human cardiac sodium channel (SCN5A) promoter

20 Nov 2003

Abstract excerpt

OBJECTIVE: Despite the primacy of the sodium current in cardiac electrophysiology and evidence that decreased sodium current is arrhythmogenic in humans, little is known about transcriptional regulation of the underlying gene, SCN5A. METHODS: We have cloned a 2.7 kb segment of 5'-flanking region of SCN5A and identified multiple transcription initiation sites by primer extension and RNase protection. Transient...

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Identifiers

PMID: 14732202
DOI: 10.1016/j.cardiores.2003.09.030

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