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Article

SCN5A channelopathy: arrhythmia, cardiomyopathy, epilepsy and beyond.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 19 Jun 2023

Remme Carol Ann

Abstract excerpt

Influx of sodium ions through voltage-gated sodium channels in cardiomyocytes is essential for proper electrical conduction within the heart. Both acquired conditions associated with sodium channel dysfunction (myocardial ischaemia, heart failure) as well as inherited disorders secondary to mutations in the gene SCN5A encoding for the cardiac sodium channel Nav1.5 are associated with life-threatening arrhythmias....

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Identifiers

PMID: 37122208
DOI: 10.1098/rstb.2022.0164
PMCID: PMC10150216

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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