Article

Upstream alternative polyadenylation in <i>SCN5A</i> produces a short transcript isoform encoding a mitochondria-localized NaV1.5 N-terminal fragment that influences cardiomyocyte respiration

2024-08-10

Abstract excerpt

<h4>SUMMARY</h4> SCN5A encodes the cardiac voltage-gated Na+ channel, NaV1.5, that initiates action potentials. SCN5A gene variants cause arrhythmias and increased heart failure risk. Mechanisms controlling NaV1.5 expression and activity are not fully understood. We recently found a well-conserved alternative polyadenylation (APA) signal downstream of the first SCN5A coding exon. This yields a SCN5A-short tran...

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Literature Corpus work: 376406c9-0fa7-5595-8a96-5051761487b5
DOI: 10.1101/2024.08.09.607406

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Upstream alternative polyadenylation in <i>SCN5A</i> produces a short transcript isoform encoding a mitochondria-localized NaV1.5 N-terminal fragment that influences cardiomyocyte respirationDOI 10.1101/2024.08.09.607406Read

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