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Article

Alternative splicing of the cardiac sodium channel creates multiple variants of mutant T1620K channels.

PloS one - 28 Apr 2011

Walzik Stefan, Schroeter Annett, Benndorf Klaus, Zimmer Thomas

Abstract excerpt

Alternative splicing creates several Na(v)1.5 transcripts in the mammalian myocardium and in various other tissues including brain, dorsal root ganglia, breast cancer cells as well as neuronal stem cell lines. In total nine Na(v)1.5 splice variants have been discovered. Four of them, namely Na(v)1.5a, Na(v)1.5c, Na(v)1.5d, and Na(v)1.5e, generate functional channels in heterologous expression systems. The...

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Identifiers

PMID: 21552533
DOI: 10.1371/journal.pone.0019188
PMCID: PMC3084281

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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