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Article

Heart Failure–Associated Changes in RNA Splicing of Sarcomere Genes

3 Feb 2010

Abstract excerpt

BACKGROUND: Alternative mRNA splicing is an important mechanism for regulation of gene expression. Altered mRNA splicing occurs in association with several types of cancer, and a small number of disease-associated changes in splicing have been reported in heart disease. However, genome-wide approaches have not been used to study splicing changes in heart disease. We hypothesized that mRNA splicing is different in...

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PMID: 20124440
DOI: 10.1161/circgenetics.109.904698

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