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Article

NOTCH1 mutation can be an early, prenatal genetic event in T-ALL.

Blood - 1 Jan 2008

Eguchi-Ishimae Minenori, Eguchi Mariko, Kempski Helena, Greaves Mel

Abstract excerpt

NOTCH1 mutations are common in T-lineage acute lymphoblastic leukemia (T-ALL). Twin studies and retrospective screening of neonatal blood spots provide evidence that fusion genes and other chromosomal abnormalities associated with pediatric leukemias can originate prenatally. Whether this is also the case for NOTCH1 mutations is unknown. Eleven cases of T-ALL were screened for NOTCH1 mutations and 4 (36%) had...

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Share to Fetal Diseases
Share to Gene Expression Regulation, Leukemic
Share to Genetic Testing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Infant, Newborn

Share to Leukemia, T-Cell

Share to Neonatal Screening

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Receptor, Notch1

Source

Identifiers

PMID: 17901244
DOI: 10.1182/blood-2007-02-074690

Genes

NOTCH1
TAL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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NOTCH1 mutation can be an early, prenatal genetic event in T-ALL.PMID 17901244Read ↗

T-cell lymphoblastic leukemia in early childhood presents NOTCH1 mutations and MLL rearrangements.Semantic proximity Read ↗

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Mutations in the HD and PEST domain of Notch-1 receptor in T-cell acute lymphoblastic leukemia: report of novel mutations from Indian population.Semantic proximity Read ↗

Notch Partners in the Long Journey of T-ALL Pathogenesis.Semantic proximity Read ↗

Decoding NOTCH1: From T-Cell Development Guardian to Driver of Pediatric T-Cell Lymphoblastic Lymphoma.Semantic proximity Read ↗

[Characteristics of NOTCH1 mutation in adult T-cell acute lymphoblastic leukemia].Semantic proximity Read ↗

Identification of novel NOTCH1 mutations: increasing our knowledge of the NOTCH signaling pathway.Semantic proximity Read ↗

Significance of NOTCH1 mutations détections in T-acute lymphoblastic leukemia patients.Semantic proximity Read ↗

Prognostic significance of NOTCH1 and FBXW7 mutations in pediatric T-ALL.Semantic proximity Read ↗

Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia.Semantic proximity Read ↗

PEST domain NOTCH mutations confer a poor relapse free survival in pediatric T-ALL: Data from a tertiary care centre in India.Semantic proximity Read ↗

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