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Article

Decoding NOTCH1: From T-Cell Development Guardian to Driver of Pediatric T-Cell Lymphoblastic Lymphoma.

International journal of molecular sciences - 23 Feb 2026

Leijnen Fran, Lammens Tim

Abstract excerpt

T-cell lymphoblastic lymphoma (T-LBL) is an aggressive malignancy of immature T-cells accounting for a substantial proportion of pediatric non-Hodgkin lymphoma cases. Current chemotherapeutic regimens achieve five-year event-free survival rates of 80-90%, yet relapse occurs in approximately 20% of patients and remains a major therapeutic challenge. This underscores the need for improved, molecularly informed...

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Topics

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Share to Cell Differentiation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Share to Receptor, Notch1

Share to Signal Transduction

Share to T-Lymphocytes

Share to Translocation, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 41752218
DOI: 10.3390/ijms27042083
PMCID: PMC12940357

Genes

NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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