Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variant of the human homologous recombination-associated gene RMI1 (S455N) impacts the risk of AML/MDS and malignant melanoma.

Cancer letters - 8 Dec 2007

Broberg Karin, Höglund Mattias, Gustafsson Cecilia, Björk Jonas, Ingvar Christian, Albin Maria, Olsson Håkan

Abstract excerpt

The newly identified protein BLAP75/RMI1 associates with the helicase BLM and is critical for the function of the homologous recombination complex. Mutations altering BLM function are associated with highly elevated cancer susceptibility (Bloom's syndrome). We have analyzed the common polymorphism Ser455Asn in RMI1 and its association with cancer risk in acute myeloid leukemia (AML, N=93), myelodysplatic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases
Share to Bloom Syndrome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Helicases

Share to Leukemia, Myeloid, Acute

Share to Melanoma

Share to Myelodysplastic Syndromes

Share to RecQ Helicases

Share to Skin Neoplasms

Source

Identifiers

PMID: 17900800
DOI: 10.1016/j.canlet.2007.08.005

Genes

RMI1
BLM

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variant of the human homologous recombination-associated gene RMI1 (S455N) impacts the risk of AML/MDS and malignant melanoma.PMID 17900800Read ↗

Association between polymorphisms in RMI1, TOP3A, and BLM and risk of cancer, a case-control study.Semantic proximity Read ↗

Looking Beyond the Cytogenetics in Haematological Malignancies- Decoding the Role of Tandem Repeats in DNA Repair GenesSemantic proximity Read ↗

Colorectal cancer and polymorphisms in DNA repair genes WRN, RMI1 and BLM.Semantic proximity Read ↗

Germline loss of <i>MBD4</i> predisposes to leukaemia due to a mutagenic cascade driven by 5mCSemantic proximity Read ↗

A genome-wide association study by ImmunoChip reveals potential modifiers in myelodysplastic syndromes.Semantic proximity Read ↗

MutS Homologues hMSH4 and hMSH5: Genetic Variations, Functions, and Implications in Human DiseasesSemantic proximity Read ↗

MutS homologue hMSH5: recombinational DSB repair and non-synonymous polymorphic variants.Semantic proximity Read ↗

Microsatellite Instability and Aberrant Pre-mRNA Splicing: How Intimate Is It?Semantic proximity Read ↗

Examining transcriptional changes to DNA replication and repair factors over uveal melanoma subtypes.Semantic proximity Read ↗

The rs61764370 Functional Variant in the KRAS Oncogene is Associated with Chronic Myeloid Leukemia Risk in Women.Semantic proximity Read ↗

TheMLH1variants p.Arg265Cys and p.Lys618Ala affect protein stability while p.Leu749Gln affects heterodimer formationSemantic proximity Read ↗

Non-Bloom syndrome-associated partial and total loss-of-function variants of BLM helicase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.