Article
Microsatellite Instability and Aberrant Pre-mRNA Splicing: How Intimate Is It?
Genes - 25 Jan 2023
Corcos Laurent, Le Scanf Enora, Quéré Gaël, Arzur Danielle, Cueff Gwennina, Jossic-Corcos Catherine Le, Le Maréchal Cédric
Abstract excerpt
Cancers that belong to the microsatellite instability (MSI) class can account for up to 15% of all cancers of the digestive tract. These cancers are characterized by inactivation, through the mutation or epigenetic silencing of one or several genes from the DNA MisMatch Repair (MMR) machinery, including MLH1, MLH3, MSH2, MSH3, MSH6, PMS1, PMS2 and Exo1. The unrepaired DNA replication errors turn into mutations at...
Topics
- Humans
- Microsatellite Instability
- RNA Precursors
- Mutation
- DNA Repair
- Colorectal Neoplasms, Hereditary Nonpolyposis