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Article

Association between polymorphisms in RMI1, TOP3A, and BLM and risk of cancer, a case-control study.

BMC cancer - 11 May 2009

Broberg Karin, Huynh Elizabeth, Schläwicke Engström Karin, Björk Jonas, Albin Maria, Ingvar Christian, Olsson Håkan, Höglund Mattias

Abstract excerpt

BACKGROUND: Mutations altering BLM function are associated with highly elevated cancer susceptibility (Bloom syndrome). Thus, genetic variants of BLM and proteins that form complexes with BLM, such as TOP3A and RMI1, might affect cancer risk as well. METHODS: In this study we have studied 26 tagged single nucleotide polymorphisms (tagSNPs) in RMI1, TOP3A, and BLM and their associations with cancer risk in acute...

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Source

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Identifiers

PMID: 19432957
DOI: 10.1186/1471-2407-9-140
PMCID: PMC2685436

Genes

BLM
RMI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association between polymorphisms in RMI1, TOP3A, and BLM and risk of cancer, a case-control study.PMID 19432957Read ↗

Genetic variant of the human homologous recombination-associated gene RMI1 (S455N) impacts the risk of AML/MDS and malignant melanoma.Semantic proximity Read ↗

The BLM-TOP3A-RMI1-RMI2 proximity map reveals that RAD54L2 suppresses sister chromatid exchangesSemantic proximity Read ↗

A case of Bloom syndrome manifesting with therapy-related myelodysplastic syndromes harboring a novel BLM gene variant.Semantic proximity Read ↗

Bloom syndrome and the underlying causes of genetic instability.Semantic proximity Read ↗

TopBP1 interacts with BLM to maintain genome stability but is dispensable for preventing BLM degradation.Semantic proximity Read ↗

High prevalence and breast cancer predisposing role of the BLM c.1642 C>T (Q548X) mutation in Russia.Semantic proximity Read ↗

Colorectal cancer and polymorphisms in DNA repair genes WRN, RMI1 and BLM.Semantic proximity Read ↗

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