Article
Vmat2 heterozygous mutant mice display a depressive-like phenotype.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 26 Sept 2007
Fukui Masato, Rodriguiz Ramona M, Zhou Jiechun, Jiang Sara X, Phillips Lindsey E, Caron Marc G, Wetsel William C
Abstract excerpt
The vesicular monoamine transporter 2 (VMAT2) is localized primarily within the CNS and is responsible for transporting monoamines from the cytoplasm into secretory vesicles. Because reserpine (a VMAT inhibitor) can precipitate depressive-like symptoms in humans, we investigated whether Vmat2 het...
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