Article
Alterations in the emotional and memory behavioral phenotypes of transient receptor potential vanilloid type 1-deficient mice are mediated by changes in expression of 5-HT₁A, GABA(A), and NMDA receptors.
Neuropharmacology - 1 Feb 2012
You In-Jee, Jung Yang-Hee, Kim Min-Jung, Kwon Seung-Hwan, Hong Sa-Ik, Lee Seok-Yong, Jang Choon-Gon
Abstract excerpt
The transient receptor potential vanilloid type 1 channel (TRPV1) receptors are expressed in various regions of the brain. Much less is known about whether TRPV1 receptors affect higher brain functions. In the present study, we demonstrated that TRPV1-knockout (TRPV1KO) mice showed antidepressant-like behaviors in a novelty-suppressed feeding test and forced swim test when compared to wild-type (WT) mice....
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