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Dopamine-transporter heterozygous rats carrying maternal wild-type allele are more vulnerable to the development of compulsive behavior.

Synapse (New York, N.Y.) - 1 Aug 2022

Festucci Fabiana, Annunzi Eugenia, Pepe Martina, Curcio Giuseppe, D'Addario Claudio, Adriani Walter

Abstract excerpt

Compulsivity is defined as an unstoppable tendency toward repetitive and habitual actions, which are reiterated despite negative consequences. Polydipsia is induced preclinically by intermittent reward, leading rodents to ingest large amounts of fluids. We focused on the role of dopamine transporter (DAT) and inheritance factors in compulsive behavior. Our sample consisted of DAT heterozygous (HET) rats with...

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PMID: 35772468
DOI: 10.1002/syn.22244

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