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Article

Sex-dependent adaptive changes in serotonin-1A autoreceptor function and anxiety in Deaf1-deficient mice.

Molecular brain - 3 Aug 2016

Luckhart Christine, Philippe Tristan J, Le François Brice, Vahid-Ansari Faranak, Geddes Sean D, Béïque Jean-Claude, Lagace Diane C, Daigle Mireille, Albert Paul R

Abstract excerpt

The C (-1019) G rs6295 promoter polymorphism of the serotonin-1A (5-HT1A) receptor gene is associated with major depression in several but not all studies, suggesting that compensatory mechanisms mediate resilience. The rs6295 risk allele prevents binding of the repressor Deaf1 increasing 5-HT1A receptor gene transcription, and the Deaf1-/- mouse model shows an increase in 5-HT1A autoreceptor expression. In this...

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Identifiers

PMID: 27488351
DOI: 10.1186/s13041-016-0254-y
PMCID: PMC4973060

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