Article
Critical roles for the M3-S2 transduction linker domain in kainate receptor assembly and postassembly trafficking.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 26 Sept 2007
Vivithanaporn Pornpun, Lash Laura Leanne, Marszalec William, Swanson Geoffrey T
Abstract excerpt
Kainate receptors (KARs) are neuronal proteins that exhibit a highly polarized distribution in the mammalian CNS. Assembly, intracellular trafficking, and synaptic targeting of KARs and other ionotropic glutamate receptors are processes controlled, in part, by various determinants within the constituent subunit proteins themselves. Here, we demonstrate that the linker region between the M3 and S2 domains, which...
Topics
- Animals
- Cell Membrane
- Hippocampus
- Mutation
- Neurons
- Protein Structure, Tertiary
- Protein Transport
- Rats
- Rats, Sprague-Dawley
- Receptors, Kainic Acid
- GluK2 Kainate Receptor