Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct Structural Pathways Coordinate the Activation of AMPA Receptor-Auxiliary Subunit Complexes.

Neuron - 16 Mar 2016

Dawe G Brent, Musgaard Maria, Aurousseau Mark R P, Nayeem Naushaba, Green Tim, Biggin Philip C, Bowie Derek

Abstract excerpt

Neurotransmitter-gated ion channels adopt different gating modes to fine-tune signaling at central synapses. At glutamatergic synapses, high and low activity of AMPA receptors (AMPARs) is observed when pore-forming subunits coassemble with or without auxiliary subunits, respectively. Whether a common structural pathway accounts for these different gating modes is unclear. Here, we identify two structural motifs...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Electric Stimulation
Share to Glutamic Acid

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Ion Channel Gating

Share to Lithium

Share to Membrane Potentials

Share to Patch-Clamp Techniques

Share to Receptors, AMPA

Share to Static Electricity

Source

Open in PubMed Open full text

Identifiers

PMID: 26924438
DOI: 10.1016/j.neuron.2016.01.038
PMCID: PMC4819453

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct Structural Pathways Coordinate the Activation of AMPA Receptor-Auxiliary Subunit Complexes.PMID 26924438Read ↗

Diversity in AMPA receptor complexes in the brain.Semantic proximity Read ↗

Engineering defined membrane-embedded elements of AMPA receptor induces opposing gating modulation by cornichon 3 and stargazin.Semantic proximity Read ↗

Assembly and stoichiometry of the AMPA receptor and transmembrane AMPA receptor regulatory protein complex.Semantic proximity Read ↗

Mechanisms underlying TARP modulation of the GluA1/2-γ8 AMPA receptor.Semantic proximity Read ↗

Identification of critical functional determinants of kainate receptor modulation by auxiliary protein Neto2.Semantic proximity Read ↗

An NMDA receptor gating mechanism developed from MD simulations reveals molecular details underlying subunit-specific contributions.Semantic proximity Read ↗

AMPA receptor activation; not a square dance.Semantic proximity Read ↗

Gating motions underlie AMPA receptor secretion from the endoplasmic reticulum.Semantic proximity Read ↗

The impact of subunit type, alternative splicing, and auxiliary proteins on AMPA receptor traffickingSemantic proximity Read ↗

AMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability.Semantic proximity Read ↗

Emerging models of glutamate receptor ion channel structure and function.Semantic proximity Read ↗

AMPA receptor trafficking and the mechanisms underlying synaptic plasticity and cognitive agingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.