Article
Distinct Structural Pathways Coordinate the Activation of AMPA Receptor-Auxiliary Subunit Complexes.
Neuron - 16 Mar 2016
Dawe G Brent, Musgaard Maria, Aurousseau Mark R P, Nayeem Naushaba, Green Tim, Biggin Philip C, Bowie Derek
Abstract excerpt
Neurotransmitter-gated ion channels adopt different gating modes to fine-tune signaling at central synapses. At glutamatergic synapses, high and low activity of AMPA receptors (AMPARs) is observed when pore-forming subunits coassemble with or without auxiliary subunits, respectively. Whether a common structural pathway accounts for these different gating modes is unclear. Here, we identify two structural motifs...
Topics
- Binding Sites
- Crystallography, X-Ray
- Electric Stimulation
- Glutamic Acid
- HEK293 Cells
- Humans
- Ion Channel Gating
- Lithium
- Membrane Potentials
- Models, Molecular
- Mutation
- Patch-Clamp Techniques
- Protein Structure, Tertiary