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Article

Structural insights into kainate receptor desensitization.

Nature communications - 9 Dec 2025

Zhou Changping, Segura-Covarrubias Guadalupe, Tajima Nami

Abstract excerpt

Kainate receptors (KARs) belong to the ionotropic glutamate receptor (iGluR) family and play critical roles in mediating excitatory neurotransmission and regulating neurotransmitter release. Receptor desensitization is a critical factor for regulating the strength of synaptic transmission. Notwithstanding their overall structural similarity to AMPA receptors, KARs exhibit a desensitized conformation that is...

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Identifiers

PMID: 41365859
DOI: 10.1038/s41467-025-65920-8
PMCID: PMC12690123

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