Article
Glutamate receptor trafficking: endoplasmic reticulum quality control involves ligand binding and receptor function.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 2 Mar 2005
Mah Stephanie J, Cornell Elizabeth, Mitchell Nicholas A, Fleck Mark W
Abstract excerpt
The glutamate receptor (GluR) agonist-binding site consists of amino acid residues in the extracellular S1 and S2 domains in the N-terminal and M3-M4 loop regions, respectively. In the present study, we sought to confirm that the conserved ligand-binding residues identified in the AMPA receptor S1S2 domains also participate in ligand binding of GluR6 kainate receptors. Amino acid substitutions were made in the...
Topics
- Amino Acid Substitution
- Binding Sites
- Biotinylation
- Blotting, Western
- Cell Line
- Dose-Response Relationship, Drug
- Dose-Response Relationship, Radiation
- Electric Stimulation
- Endoplasmic Reticulum
- Gene Expression