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Article

Glutamate receptor trafficking: endoplasmic reticulum quality control involves ligand binding and receptor function.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 2 Mar 2005

Mah Stephanie J, Cornell Elizabeth, Mitchell Nicholas A, Fleck Mark W

Abstract excerpt

The glutamate receptor (GluR) agonist-binding site consists of amino acid residues in the extracellular S1 and S2 domains in the N-terminal and M3-M4 loop regions, respectively. In the present study, we sought to confirm that the conserved ligand-binding residues identified in the AMPA receptor S1S2 domains also participate in ligand binding of GluR6 kainate receptors. Amino acid substitutions were made in the...

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Identifiers

PMID: 15745947
DOI: 10.1523/JNEUROSCI.4573-04.2005
PMCID: PMC6726086

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glutamate receptor trafficking: endoplasmic reticulum quality control involves ligand binding and receptor function.PMID 15745947Read ↗

Glutamate binding and conformational flexibility of ligand-binding domains are critical early determinants of efficient kainate receptor biogenesis.Semantic proximity Read ↗

Ligand binding is a critical requirement for plasma membrane expression of heteromeric kainate receptors.Semantic proximity Read ↗

Amino-acid residues involved in glutamate receptor 6 kainate receptor gating and desensitization.Semantic proximity Read ↗

Critical roles for the M3-S2 transduction linker domain in kainate receptor assembly and postassembly trafficking.Semantic proximity Read ↗

Cell surface expression of GluR5 kainate receptors is regulated by an endoplasmic reticulum retention signal.Semantic proximity Read ↗

Functional consequences of natural substitutions in the GluR6 kainate receptor subunit ligand-binding site.Semantic proximity Read ↗

Agonist binding to the GluK5 subunit is sufficient for functional surface expression of heteromeric GluK2/GluK5 kainate receptors.Semantic proximity Read ↗

Block of kainate receptor desensitization uncovers a key trafficking checkpoint.Semantic proximity Read ↗

Stargazin interacts functionally with the AMPA receptor glutamate-binding module.Semantic proximity Read ↗

Independent regulation of early trafficking of NMDA receptors by ligand-binding domains of the GluN1 and GluN2A subunitsSemantic proximity Read ↗

Disease-associated mutations in GluK2 disrupt compartment-specific regulatory mechanisms controlling kainate receptor membrane traffickingSemantic proximity Read ↗

Distinct Regulation of Early Trafficking of the NMDA Receptors by the Ligand-Binding Domains of the GluN1 and GluN2A Subunits.Semantic proximity Read ↗

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