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Article

Investigation into the mechanism regulating MRP localization.

Experimental cell research - 15 Jan 2008

van den Bout Iman, van Rheenen Jacco, van Angelen Annelies A, de Rooij Johan, Wilhelmsen Kevin, Jalink Kees, Divecha Nullin, Sonnenberg Arnoud

Abstract excerpt

The major PKC substrates MARCKS and MacMARCKS (MRP) are membrane-binding proteins implicated in cell spreading, integrin activation and exocytosis. According to the myristoyl-electrostatic switch model the co-operation between the myristoyl moiety and the positively charged effector domain (ED) is an essential mechanism by which proteins bind to membranes. Loss of the electrostatic interaction between the ED and...

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Source

Identifiers

PMID: 17897642
DOI: 10.1016/j.yexcr.2007.08.019

Genes

MARCKS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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