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Article

Involvement of protein phosphatase-1-mediated MARCKS translocation in myogenic differentiation of embryonic muscle cells.

Journal of cell science - 15 Jun 2002

Kim Sang Soo, Kim Jung Hwa, Lee Seung-Hye, Chung Sung Soo, Bang Ok-Sun, Park Dongeun, Chung Chin Ha

Abstract excerpt

Myristoylated alanine-rich C kinase substrate (MARCKS) translocates from the cytosol to the plasma membrane while mononucleated myoblasts fuse to form multinucleated myotubes. Here, we show that protein phosphatase-1-mediated dephosphorylation of MARCKS largely influences its subcellular localization and the fusion process. Treatment with okadaic acid or tautomycin, which are potent inhibitors of protein...

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Source

Identifiers

PMID: 12045217
DOI: 10.1242/jcs.115.12.2465

Genes

MARCKS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Involvement of protein phosphatase-1-mediated MARCKS translocation in myogenic differentiation of embryonic muscle cells.PMID 12045217Read ↗

Transgenic complementation of MARCKS deficiency with a nonmyristoylatable, pseudo-phosphorylated form of MARCKS: evidence for simultaneous positive and dominant-negative effects on central nervous system development.Semantic proximity Read ↗

Modulation of Thr phosphorylation of integrin beta1 during muscle differentiation.Semantic proximity Read ↗

MARCKS regulates membrane ruffling and cell spreading.Semantic proximity Read ↗

Phosphatidylinositol phosphate-dependent regulation of Xenopus ENaC by MARCKS protein.Semantic proximity Read ↗

Two myristoylated alanine-rich C-kinase substrate (MARCKS) paralogs are required for normal development in zebrafish.Semantic proximity Read ↗

Inactivation of Rho/ROCK signaling is crucial for the nuclear accumulation of FKHR and myoblast fusion.Semantic proximity Read ↗

Myristoylation alters retinoic acid-induced down-regulation of MARCKS in immortalized hippocampal cells.Semantic proximity Read ↗

Nonmyristoylated MARCKS complements some but not all of the developmental defects associated with MARCKS deficiency in mice.Semantic proximity Read ↗

Myoblast migration is prevented by a calpain-dependent accumulation of MARCKS.Semantic proximity Read ↗

The pseudophosphatase MK-STYX induces neurite-like outgrowths in PC12 cells.Semantic proximity Read ↗

MARCKS-like protein, a membrane protein identified for its expression in developing neural retina, plays a role in regulating retinal cell proliferation.Semantic proximity Read ↗

Myomaker is required for the fusion of fast-twitch myocytes in the zebrafish embryo.Semantic proximity Read ↗

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