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Article

Protein kinase C regulates MARCKS cycling between the plasma membrane and lysosomes in fibroblasts.

The EMBO journal - 15 Mar 1995

Allen L A, Aderem A

Abstract excerpt

MARCKS is a protein kinase C (PKC) substrate that is phosphorylated during neurosecretion, phagocyte activation and growth factor-dependent mitogenesis. MARCKS binds calcium/calmodulin and crosslinks F-actin, and both these activities are regulated by PKC-dependent phosphorylation. We present evidence here that PKC-dependent phosphorylation also regulates the cycling of MARCKS between the plasma membrane and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 7720702
DOI: 10.1002/j.1460-2075.1995.tb07094.x
PMCID: PMC398188

Genes

MARCKS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Protein kinase C regulates MARCKS cycling between the plasma membrane and lysosomes in fibroblasts.PMID 7720702Read ↗

Proteomic analysis reveals a role for protein kinase C-alpha in phagosome maturation.Semantic proximity Read ↗

MARCKS regulates membrane ruffling and cell spreading.Semantic proximity Read ↗

Lack of palmitoylation redirects p59Hck from the plasma membrane to p61Hck-positive lysosomes.Semantic proximity Read ↗

Involvement of protein phosphatase-1-mediated MARCKS translocation in myogenic differentiation of embryonic muscle cells.Semantic proximity Read ↗

Myristoylation alters retinoic acid-induced down-regulation of MARCKS in immortalized hippocampal cells.Semantic proximity Read ↗

Investigation into the mechanism regulating MRP localization.Semantic proximity Read ↗

Inhibition of phosphatidylinositol-4-phosphate 5-kinase Ialpha impairs localized actin remodeling and suppresses phagocytosis.Semantic proximity Read ↗

Serine and threonine phosphorylation of the low density lipoprotein receptor-related protein by protein kinase Calpha regulates endocytosis and association with adaptor molecules.Semantic proximity Read ↗

Adducin is an in vivo substrate for protein kinase C: phosphorylation in the MARCKS-related domain inhibits activity in promoting spectrin-actin complexes and occurs in many cells, including dendritic spines of neurons.Semantic proximity Read ↗

Structural requirements for localization and activation of protein kinase C mu (PKC mu) at the Golgi compartment.Semantic proximity Read ↗

MacMARCKS mutation blocks macrophage phagocytosis of zymosan.Semantic proximity Read ↗

Myoblast migration is prevented by a calpain-dependent accumulation of MARCKS.Semantic proximity Read ↗

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