Article
Protein kinase C regulates MARCKS cycling between the plasma membrane and lysosomes in fibroblasts.
The EMBO journal - 15 Mar 1995
Allen L A, Aderem A
Abstract excerpt
MARCKS is a protein kinase C (PKC) substrate that is phosphorylated during neurosecretion, phagocyte activation and growth factor-dependent mitogenesis. MARCKS binds calcium/calmodulin and crosslinks F-actin, and both these activities are regulated by PKC-dependent phosphorylation. We present evi...
Topics
- Alkaloids
- Ammonium Chloride
- Animals
- Antigens, CD
- Biological Transport
- Cell Membrane
- Enzyme Activation
- Fibroblasts
- Intracellular Signaling Peptides and Proteins
- Lysosomal Membrane Proteins
- Lysosomes
- Membrane Glycoproteins
- Membrane Proteins
- Mice
- Mice, Inbred ICR
- Microtubules
- Mutation
- Myristoylated Alanine-Rich C Kinase Substrate