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Article

The INT6 Cancer Gene and MEK Signaling Pathways Converge during Zebrafish Development

26 Sept 2007

Abstract excerpt

BACKGROUND: Int-6 (integration site 6) was identified as an oncogene in a screen of tumorigenic mouse mammary tumor virus (MMTV) insertions. INT6 expression is altered in human cancers, but the precise role of disrupted INT6 in tumorigenesis remains unclear, and an animal model to study Int-6 physiological function has been lacking. PRINCIPAL FINDINGS: Here, we create an in vivo model of Int6 function in...

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PMID: 17895999
DOI: 10.1371/journal.pone.0000959

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