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Article

Int-6, a highly conserved, widely expressed gene, is mutated by mouse mammary tumor virus in mammary preneoplasia.

Journal of virology - 1 Mar 1995

Marchetti A, Buttitta F, Miyazaki S, Gallahan D, Smith G H, Callahan R

Abstract excerpt

With a unique mouse mammary tumor model system in which mouse mammary tumor virus (MMTV) insertional mutations can be detected during progression from preneoplasia to frank malignancy, including metastasis, we have discovered a new common integration site (designated Int-6) for MMTV in mouse mammary tumors. MMTV was integrated into Int-6 in a mammary hyperplastic outgrowth line, its tumors and metastases, and two...

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Identifiers

PMID: 7853537
DOI: 10.1128/JVI.69.3.1932-1938.1995
PMCID: PMC188811

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