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Article

PP6 Disruption Synergizes with Oncogenic Ras to Promote JNK-Dependent Tumor Growth and Invasion.

Cell reports - 27 Jun 2017

Ma Xianjue, Lu Jin-Yu, Dong Yongli, Li Daming, Malagon Juan N, Xu Tian

Abstract excerpt

RAS genes are frequently mutated in cancers, yet an effective treatment has not been developed, partly because of an incomplete understanding of signaling within Ras-related tumors. To address this, we performed a genetic screen in Drosophila, aiming to find mutations that cooperate with oncogenic Ras (RasV12) to induce tumor overgrowth and invasion. We identified fiery mountain (fmt), a regulatory subunit of the...

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Identifiers

PMID: 28658615
DOI: 10.1016/j.celrep.2017.05.092
PMCID: PMC5580353

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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