Article
Evidence for the transforming activity of a truncated Int6 gene, in vitro.
Oncogene - 30 Aug 2001
Rasmussen S B, Kordon E, Callahan R, Smith G H
Abstract excerpt
Int6/eIF3-p48 was first identified as a common integration site for MMTV in mouse mammary tumors. In all cases, the MMTV integration event resulted in an interruption of the normal Int6 transcript from one allele leaving the second allele intact and operative. We hypothesize that insertion of MMTV into Int6 results in a mutated allele that encodes a shortened Int6 mRNA and protein (Int6sh), which either modifies...
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