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Article

MEK genomics in development and disease.

Briefings in functional genomics - 1 Jul 2012

Bromberg-White Jennifer L, Andersen Nicholas J, Duesbery Nicholas S

Abstract excerpt

The mitogen-activated protein kinase kinases (the MAPK/ERK kinases; MKKs or MEKs) and their downstream substrates, the extracellular-regulated kinases have been intensively studied for their roles in development and disease. Until recently, it had been assumed any mutation affecting their function would have lethal consequences. However, the identification of MEK1 and MEK2 mutations in developmental syndromes as...

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Identifiers

PMID: 22753777
DOI: 10.1093/bfgp/els022
PMCID: PMC3398258

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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