Divergent effects of intrinsically active MEK variants on developmental Ras signaling.

Abstract excerpt

Germline mutations in Ras pathway components are associated with a large class of human developmental abnormalities, known as RASopathies, that are characterized by a range of structural and functional phenotypes, including cardiac defects and neurocognitive delays. Although it is generally believed that RASopathies are caused by altered levels of pathway activation, the signaling changes in developing tissues...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Drosophila melanogaster
• Share to Germ-Line Mutation