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Article

Age-specific induction of mutant p53 drives clonal hematopoiesis and acute myeloid leukemia in adult mice.

Cell reports. Medicine - 21 May 2024

Pourebrahim Rasoul, Montoya Rafael Heinz, Akiyama Hiroki, Ostermann Lauren, Khazaei Shayuan, Muftuoglu Muharrem, Baran Natalia, Zhao Ran, Lesluyes Tom, Liu Bin, Khoury Joseph D, Gagea Mihai, Van Loo Peter, Andreeff Michael

Abstract excerpt

The investigation of the mechanisms behind p53 mutations in acute myeloid leukemia (AML) has been limited by the lack of suitable mouse models, which historically have resulted in lymphoma rather than leukemia. This study introduces two new AML mouse models. One model induces mutant p53 and Mdm2 haploinsufficiency in early development, showing the role of Mdm2 in myeloid-biased hematopoiesis and AML...

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Share to Clonal Hematopoiesis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hematopoietic Stem Cells

Share to Leukemia, Myeloid, Acute

Share to Mice, Inbred C57BL

Share to Proto-Oncogene Proteins c-mdm2

Share to Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 38733986
DOI: 10.1016/j.xcrm.2024.101558
PMCID: PMC11148800

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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