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Article

The ups and downs of p53 regulation in hematopoietic stem cells.

Cell cycle (Georgetown, Tex.) - 1 Oct 2011

Abbas Hussein A, Pant Vinod, Lozano Guillermina

Abstract excerpt

Hematopoietic stem cells provide an indispensible source for replenishing the blood with all its constituents throughout the organism's lifetime. Mice with a compromised hematopoietic stem cell compartment cannot survive. p53, a major tumor suppressor gene, has been implicated in regulation of hematopoiesis. In particular, p53 plays a role in homeostasis by regulating HSC quiescence and self renewal. We recently...

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Identifiers

PMID: 21957490
DOI: 10.4161/cc.10.19.17721
PMCID: PMC3233622

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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