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Article

Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development.

Molecular and cellular biology - 1 Aug 2002

Migliorini Domenico, Lazzerini Denchi Eros, Danovi Davide, Jochemsen Aart, Capillo Manuela, Gobbi Alberto, Helin Kristian, Pelicci Pier Giuseppe, Marine Jean-Christophe

Abstract excerpt

We report here the characterization of a mutant mouse line with a specific gene trap event in the Mdm4 locus. Absence of Mdm4 expression results in embryonic lethality (10.5 days postcoitum [dpc]), which was rescued by transferring the Mdm4 mutation into a Trp53-null background. Mutant embryos were characterized by overall growth deficiency, anemia, improper neural tube closure, and dilation of lateral...

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Identifiers

PMID: 12101245
DOI: 10.1128/MCB.22.15.5527-5538.2002
PMCID: PMC133932

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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