Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of genetic polymorphisms in the transforming growth factor-beta1 gene and the risk of Alzheimer's disease.

Human genetics - 1 May 2000

Luedecking E K, DeKosky S T, Mehdi H, Ganguli M, Kamboh M I

Abstract excerpt

Alzheimer's disease (AD) is a complex disease involving several genetic and environmental components. Genetic studies have yet to identify all the genes involved in the pathogenesis of AD. Transforming growth factor-beta1 (TGF-beta1) is a candidate gene for AD. It is a multifunctional cytokine whose overexpression has been shown to promote the deposition of amyloid-beta peptide. The goal of this study was to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to COS Cells
Share to DNA Primers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Reporter

Share to Luciferases

Share to Promoter Regions, Genetic

Share to Transfection

Share to Transforming Growth Factor beta

Source

Identifiers

PMID: 10914688
DOI: 10.1007/s004390000313

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of genetic polymorphisms in the transforming growth factor-beta1 gene and the risk of Alzheimer's disease.PMID 10914688Read ↗

Association studies of transforming growth factor-beta 1 and Alzheimer's disease.Semantic proximity Read ↗

Role of the Transforming-Growth-Factor-β1 Gene in Late-Onset Alzheimer’s Disease: Implications for the TreatmentSemantic proximity Read ↗

+10 T/C polymorphisms in the gene of transforming growth factor-beta1 are associated with neurodegeneration and its clinical evolution.Semantic proximity Read ↗

Association study of three polymorphisms of TGF-beta1 gene with Alzheimer's disease.Semantic proximity Read ↗

Association between polymorphisms in transforming growth factor-β1 and sporadic Alzheimer's disease in a Chinese population.Semantic proximity Read ↗

Meta-analysis of the transforming growth factor-β1 polymorphisms and susceptibility to Alzheimer's disease.Semantic proximity Read ↗

The CC genotype of transforming growth factor-β1 increases the risk of late-onset Alzheimer's disease and is associated with AD-related depression.Semantic proximity Read ↗

Polymorphisms in the interleukin 6 and transforming growth factor beta1 gene and risk of dementia. The Rotterdam Study.Semantic proximity Read ↗

Interleukin-18 promoter polymorphisms and risk of late onset Alzheimer's disease.Semantic proximity Read ↗

Association between the interleukin-1alpha gene and Alzheimer's disease: a meta-analysis.Semantic proximity Read ↗

Tumor Necrosis Factor α and Interleukin 10 Promoter Region Polymorphisms and Risk of Late-Onset Alzheimer DiseaseSemantic proximity Read ↗

A megalin polymorphism associated with promoter activity and Alzheimer's disease risk.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.