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Article

Association study of three polymorphisms of TGF-beta1 gene with Alzheimer's disease.

Journal of neurology, neurosurgery, and psychiatry - 1 Jul 2002

Araria-Goumidi L, Lambert J C, Mann D M A, Lendon C, Frigard B, Iwatsubo T, Cottel D, Amouyel P, Chartier-Harlin M C

Abstract excerpt

BACKGROUND: There is evidence that inflammatory processes may contribute to the development of Alzheimer's disease through production of cytokines and free radicals that damage neurones. A recent study has shown that transforming growth factor beta1 (TGF-beta1) signalling in astrocytes promotes Abeta production and could play a critical role in the formation of amyloid plaques in the brain. OBJECTIVES: To explore...

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Identifiers

PMID: 12082048
DOI: 10.1136/jnnp.73.1.62
PMCID: PMC1757290

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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