The CC genotype of transforming growth factor-β1 increases the risk of late-onset Alzheimer's disease and is associated with AD-related depression.

doi:10.1016/j.euroneuro.2011.08.006

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Article

The CC genotype of transforming growth factor-β1 increases the risk of late-onset Alzheimer's disease and is associated with AD-related depression.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Apr 2012

Caraci Filippo, Bosco Paolo, Signorelli Maria, Spada Rosario S, Cosentino Filomena I, Toscano Giuseppe, Bonforte Cinzia, Muratore Stefano, Prestianni Giuseppina, Panerai Simonetta, Giambirtone Maria Concetta, Gulotta Eleonora, Romano Carmelo, Salluzzo Maria Grazia, Nicoletti Ferdinando, Copani Agata, Drago Filippo, Aguglia Eugenio, Ferri Raffaele

Abstract excerpt

Transforming growth factor-β1 (TGF-β1) is a neurotrophic factor that exerts neuroprotective effects against β-amyloid-induced neurodegeneration. Recently, a specific impairment of the TGF-β1 signaling pathway has been demonstrated in Alzheimer's disease (AD) brain. TGF-β1 is also involved in the pathogenesis of depressive disorders, which may occur in 30-40% of AD patients. The TGF-β1 gene contains single...

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PMID: 21924590
DOI: 10.1016/j.euroneuro.2011.08.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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