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Article

Molecular evolution and balancing selection in the flavin-containing monooxygenase 3 gene (FMO3).

Pharmacogenetics and genomics - 1 Oct 2007

Allerston Charles K, Shimizu Makiko, Fujieda Masaki, Shephard Elizabeth A, Yamazaki Hiroshi, Phillips Ian R

Abstract excerpt

OBJECTIVES: Flavin-containing monooxygenase 3 (FMO3) is involved in the metabolism of foreign chemicals, including therapeutic drugs, and thus mediates interactions between humans and their chemical environment. Loss-of-function mutations in the gene cause the inherited disorder trimethylaminuria, or fish-odour syndrome. The objective was to gain insights into the evolutionary history of FMO3. METHODS: Genetic...

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Source

Identifiers

PMID: 17885620
DOI: 10.1097/FPC.0b013e328256b198

Genes

FMO3
FST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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