Article
Three novel single nucleotide polymorphisms of the FMO3 gene in a Japanese population.
Drug metabolism and pharmacokinetics - 1 Jun 2006
Shimizu Makiko, Fujita Haruka, Aoyama Takahiko, Yamazaki Hiroshi
Abstract excerpt
We sequenced all exons and exon-intron junctions of the flavin-containing monooxygenase 3 (FMO3) gene from 2 Japanese individuals and their family members, who were case subjects that showed low FMO3 metabolic capacity among a population of self-reported trimethylaminuria Japanese volunteers. We found two novel single nucleotide polymorphisms (SNPs) (21,254 C>A and 24,006 A>G) causing amino acid substitutions,...
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