Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular variants of the thiazide-sensitive Na+-Cl- cotransporter in hypertensive families.

Journal of hypertension - 1 Oct 2007

Keszei András P, Tislér András, Backx Peter H, Andrulis Irene L, Bull Shelley B, Logan Alexander G

Abstract excerpt

BACKGROUND: The thiazide-sensitive Na-Cl cotransporter (TSC) is involved in the fine regulation of sodium excretion by the kidney, and an increase in its activity causes salt-sensitive hypertension and hypercalciuria. METHODS: To explore the possibility that activating mutations in the TSC gene may be involved in the pathogenesis of primary hypertension, we screened genomic DNA of 68 individuals from hypertensive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to In Vitro Techniques
Share to Kidney Tubules

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oocytes

Share to Receptors, Drug

Share to Sodium Chloride Symporters

Share to Solute Carrier Family 12, Member 3

Share to Symporters

Share to Xenopus laevis

Source

Identifiers

PMID: 17885550
DOI: 10.1097/HJH.0b013e3282a9be1b

Genes

WNK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular variants of the thiazide-sensitive Na+-Cl- cotransporter in hypertensive families.PMID 17885550Read ↗

Thiazide-sensitive Na+-Cl- cotransporter: genetic polymorphisms and human diseases.Semantic proximity Read ↗

G2736A polymorphism of thiazide-sensitive Na-Cl cotransporter gene predisposes to hypertension in young women.Semantic proximity Read ↗

Association study of variants in two ion-channel genes (TSC and CLCNKB) and hypertension in two ethnic groups in Northwest China.Semantic proximity Read ↗

[Clinical significance of thiazide-sensitive Na-Cl cotransporter gene by mutational analysis].Semantic proximity Read ↗

Molecular insights from dysregulation of the thiazide-sensitive WNK/SPAK/NCC pathway in the kidney: Gordon syndrome and thiazide-induced hyponatraemia.Semantic proximity Read ↗

Identification of 108 SNPs in TSC, WNK1, and WNK4 and their association with hypertension in a Japanese general population.Semantic proximity Read ↗

Non-association of the thiazide-sensitive Na,Cl-cotransporter gene with polygenic hypertension in both rats and humans.Semantic proximity Read ↗

[Association of thiazide-sensitive Na+-Cl* cotransporter gene polymorphisms with the risk of essential hypertension].Semantic proximity Read ↗

The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics.Semantic proximity Read ↗

A single nucleotide polymorphism alters the activity of the renal Na+:Cl- cotransporter and reveals a role for transmembrane segment 4 in chloride and thiazide affinity.Semantic proximity Read ↗

Association of TSC gene variants and hypertension in Mongolian and Han populations.Semantic proximity Read ↗

Thiazide-induced hyponatraemia: epidemiology and clues to pathogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.